VDR is a gene which encodes a protein that acts as a receptor vitamin D that regulates bone formation and calcium absorption. A variant of the gene known as rs2228570 (FokI polymorphism) is associated with a decrease in bone mineral density in white prepubertal girls.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is regulated by the temporal and reciprocal pattern of on- and off occupancy of the VDRE by the two components, and it is influenced by chromosomal location and data room de binding preferences for certain hormones. Microarray studies of human cells indicate that more than 100 genes possess an identifiable VDRE in their promoters. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual dataroom (VDR) can be a repository of data and documents that are relevant to legal transactions, business, or proceedings. Access to the data, downloading, or printing are not permitted. It makes use of a central server as well as an extranet connection which is an Internet connection that has restricted access to allow controlled login time periods during which users are able to browse the documents and data.
VDRs are used most often by investment banks and businesses involved in mergers and acquisitions. They must be able to communicate information in a clear way with potential investors or buyers. Due diligence processes can also require a substantial amount of information. Life science companies also use VDRs to store everything from clinical trials results to HIPAA documentation.